Immunoglobulin G Locus Events in Soft Tissue Sarcoma Cell Lines

Immunoglobulin G Locus Events in Soft Tissue Sarcoma Cell Lines

Recently immunoglobulins (Igs) have been found to be expressed by cells other than B lymphocytes, including various human carcinoma cells. Sarcomas are derived from mesenchyme, and the knowledge about the occurrence of Ig production in sarcoma cells is very limited. Here we investigated the phenomenon of immunoglobulin G (IgG) expression and its molecular basis in 3 sarcoma cell lines. The mRNA...

Soft tissue tumors: Clear cell sarcoma

P. Radiosensitivity in Vitro of Human Soft Tissue Sarcoma Cell Lines and Skin Fibroblasts Derived From

The Scientific Community, concerned about animal welfare, is sensitive to concerns regarding how and why animals are used in biomedical research and testing to evaluate the toxicological potential of various substances. Although alternatives to methods based on the use of animals may not satisfy all requirements and needs of the biomedical research and toxicologic testing communities, alternati...

Intrinsic resistance to methotrexate in human soft tissue sarcoma cell lines.

A human fibrosarcoma cell line, HT-1080, and four new cell lines (HS-16, HS-28, HS-30, and HS-42) were established from untreated patients with mesenchymal chondrosarcoma, peripheral nerve sheath sarcoma, malignant hemangiopericytoma, and mixed mesodermal tumor, respectively, and were used for analysis of mechanisms of intrinsic resistance to methotrexate. All four new cell lines were resistant...

Soft tissue sarcoma.

Soft tissue sarcomas are rare tumours of the connective tissue. The knowledge of this rare entity is necessary for an accurate diagnosis. The incidence in Europe is about 3,6/100 000 per year. The first line treatment consists of a wide resection of the tumour, possibly combined with an adjuvant radiation therapy. A chemotherapy can be indicated and has to be evaluated for each case individuall...